LeHavreV1, France, Analysis, bibRecord, 001601

Haemodialysis of pyrazinamide in uraemic patients

Identifieur interne : 001601 ( France/Analysis ); précédent : 001600; suivant : 001602

Haemodialysis of pyrazinamide in uraemic patients

Auteurs : C. Lacroix [France] ; A. Hermelin [France] ; R. Guiberteau [France] ; C. Guyonnaud [France] ; J. Nouveau [France] ; H. Duwoos [France] ; O. Lafont [France]

Source :

European Journal of Clinical Pharmacology [ 0031-6970 ] ; 1989-05-01.

RBID : ISTEX:B727ECFFFAE073551F411AEA83F18F3A11ABF76C

English descriptors

KwdEn :
- Adult, Biotransformation, Chromatography, High Pressure Liquid, Female, Humans, Male, Pyrazinamide (blood), Pyrazinamide (metabolism), Pyrazinamide (pharmacokinetics), Renal Dialysis, Uremia (blood).
MESH :
- chemical , blood : Pyrazinamide.
- chemical , metabolism : Pyrazinamide.
- chemical , pharmacokinetics : Pyrazinamide.
- blood : Uremia.
- Adult, Biotransformation, Chromatography, High Pressure Liquid, Female, Humans, Male, Renal Dialysis.

Abstract

Summary: The pharmacokinetics of PZA during haemodialysis were determined in 6 patients with chronic renal impairment after a single oral dose of 25.7 (1.9) mg·kg−1. The dialysis clearance of PZA and of its metabolites were: pyrazinamide 132 ml·min−1; pyrazinoic acid 121 ml·min−1; 5-hydroxy-pyrazinamide 107 ml·min−1; 5-hydroxy-pyrazinoic acid 118 ml·min−1. The average amount extracted during a dialysis session of 4.1 h was 926 mg after an oral dose of 1700 mg. The high dialysability shows that PZA can property be administered at the end of each dialysis session in the usual dose of 25 to 30 mg·kg−1.

Url:

https://api.istex.fr/document/B727ECFFFAE073551F411AEA83F18F3A11ABF76C/fulltext/pdf

DOI: 10.1007/BF00679791

Affiliations:

Links to Exploration step

ISTEX:B727ECFFFAE073551F411AEA83F18F3A11ABF76C

Le document en format XML

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<author><name sortKey="Hermelin, A" sort="Hermelin, A" uniqKey="Hermelin A" first="A." last="Hermelin">A. Hermelin</name>
</author>
<author><name sortKey="Guiberteau, R" sort="Guiberteau, R" uniqKey="Guiberteau R" first="R." last="Guiberteau">R. Guiberteau</name>
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<author><name sortKey="Guyonnaud, C" sort="Guyonnaud, C" uniqKey="Guyonnaud C" first="C." last="Guyonnaud">C. Guyonnaud</name>
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<author><name sortKey="Nouveau, J" sort="Nouveau, J" uniqKey="Nouveau J" first="J." last="Nouveau">J. Nouveau</name>
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<author><name sortKey="Duwoos, H" sort="Duwoos, H" uniqKey="Duwoos H" first="H." last="Duwoos">H. Duwoos</name>
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<wicri:noRegion>Saint-Etienne du Rouvray</wicri:noRegion>
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<term>Pyrazinamide (pharmacokinetics)</term>
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<front><div type="abstract" xml:lang="en">Summary: The pharmacokinetics of PZA during haemodialysis were determined in 6 patients with chronic renal impairment after a single oral dose of 25.7 (1.9) mg·kg−1. The dialysis clearance of PZA and of its metabolites were: pyrazinamide 132 ml·min−1; pyrazinoic acid 121 ml·min−1; 5-hydroxy-pyrazinamide 107 ml·min−1; 5-hydroxy-pyrazinoic acid 118 ml·min−1. The average amount extracted during a dialysis session of 4.1 h was 926 mg after an oral dose of 1700 mg. The high dialysability shows that PZA can property be administered at the end of each dialysis session in the usual dose of 25 to 30 mg·kg−1.</div>
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Haemodialysis of pyrazinamide in uraemic patients

Haemodialysis of pyrazinamide in uraemic patients

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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